Fig. 2: Delta replication in upper and lower airways.

NHP (n = 8/group) were challenged with 2 × 10⁵ TCID₅₀ Delta and simultaneously treated with RBD-62 (green circles) or PBS (gray circles). a Subgenomic RNA encoding for N transcript was measured in the upper and lower airways at days 2, 4, 7, 9 and 14 post challenge. b Culturable virus was measured in the upper and lower airways at days 2 and 4 post challenge. Dotted lines indicate the assay limit of detection (LOD). Circles, boxes and horizontal lines represent individual animals, interquartile range and median, respectively, while minima and maxima are denoted at whisker termini. Statistical analyses were shown for comparison of groups at each timepoint and were performed using the Wilcoxon rank-sum test (two-sided) after Holm’s adjustment across timepoints. NS denotes that the indicated comparison was not significant, with P > 0.05. See also Supplementary Tables 2 and 3 for complete statistical analyses. Source data are provided as a Source Data file.