Fig. 3: Post-GWAS in silico results. | Nature Communications

Fig. 3: Post-GWAS in silico results.

From: Genetic determinants and phenotypic consequences of blood T-cell proportions in 207,000 diverse individuals

Fig. 3: Post-GWAS in silico results.The alternative text for this image may have been generated using AI.

A Data represents SNP Heritability estimates for EUR (h2SNP ~ 0.1, SD ~ 0.02) and AFR (h2SNP ~ 0.42, SD ~ 0.04) ancestry populations were calculated by the SumHer BLD-LDAK model using GWAS summary statistics (EUR N = 57,392, AFR N = 33,636). B Prioritized variants from the TOPMed single-variant association study and lead variants from the multi-cohort meta-analysis were queried from the Open Targets single-variants PheWAS. All measurement associations were previously reported as genome-wide significant (5 × 10−8) from two-sided single-variant association studies in Chen et al., 2020. The variants were sorted and classified based on their association with cells from one or more of the hematopoietic lineages.

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