Fig. 4: Structure of the TRRAP module of hTIP60 and its comparison with other complexes.

a Comparison of the binding surface of the TRRAP subunit with other subunits in hTIP60 (left) and hSAGA. The dashed circles indicate the binding surface. b Comparison of the “neck” region of hTIP60 (left) and yNuA4. The upper panels show the positions of the “neck” and the bottom panels show close-up views. The secondary structure of Eaf1 and Epl1 is derived from a structure of yNuA4 (PDB: 8ESC). c Superimposition of the hTIP60 and yNuA4 (PDB: 8ESC) models on the subunit TRRAP/tra1.