Table 2 Study design and timing of blood sample collection for serotype-specific memory B cell (Bmem) and IgG measurements

From: Memory B cell responses induced by pneumococcal conjugate vaccine schedules with fewer doses: analysis of a randomised-controlled trial in Viet Nam

Subgroup

Timepoint (age)

12 months

12 months + 7 days

12 months + 28 days

24 months

a (n = 50)

Bmema IgGb

IgG

 

IgG

b (n = 50)

IgGc

Bmem IgG

  

c (n = 50)

IgG

 

Bmem IgG

IgG

d (n = 50)

IgG

 

IgG

Bmem IgG

  1. The four vaccine arms (i.e. PCV10 0 + 1, PCV13 0 + 1, PCV10 1 + 1, and PCV13 1 + 1) included 200 participants each, which were further divided into four subgroups (i.e. a, b, c, and d) with 50 participants each.
  2. aMemory B cell blood samples for subgroup a was also used as baseline for subgroup b at 12 months.
  3. bIgG ELISA was only conducted in PCV13 0 + 1 subgroup at 12 months of age.
  4. cIgG blood samples were also collected for subgroup b at 2–3 months, but not included in this analysis.
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