Fig. 9: Expression of Mef2bP297L mutant promotes GC B cell lymphomagenesis in mice. | Nature Communications

Fig. 9: Expression of Mef2bP297L mutant promotes GC B cell lymphomagenesis in mice.

From: MEF2B C-terminal mutations enhance transcriptional activity and stability to drive B cell lymphomagenesis

Fig. 9

a Distribution of B cell lymphomas across genotypes. Colored bars indicate different diagnoses, namely follicular lymphoma (FL), diffuse large B cell lymphoma (DLBCL), and plasmablastic lymphoma (PBL). The numbers in the bars refer to the number of tumors (note that some mice bear more than one tumor type). The p values were determined by Fisher’s Exact test (two-tailed). b H&E staining and immunohistochemical analysis of selected markers in representative tumors from mice diagnosed with FL, DLBCL, or PBL. EGFP is the tracking marker of Mef2bP297L. High magnification scale bar, 10 μm. These immunohistochemical analyses were performed for all tumors. c Tumor-free survival curve. The p values were determined by Gehan-Breslow-Wilcoxon Test (two-tailed) across genotypes. Source data are provided as a Source Data file.

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