Table 2 Multivariable Mendelian randomization for smoking and alcohol consumption with risk of HNSCC by HPV status
From: Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study
Outcomes | Exposures | F statistic | Q-statistic for Instrument Validity | P value | Method | OR (95% CI) | P value |
|---|---|---|---|---|---|---|---|
HPV-negative HNSCC vs controls | CSI | 30.4 | 207.2 | 0.09 | IVW | 3.03 (1.75, 5.24) | 7.00E-05 |
MVMR Egger | 2.49 (1.40, 4.43) | 0.002 | |||||
Ridge Regression | 4.93 (2.24, 10.66) | ||||||
Drinks per Week | 6.13 | IVW | 7.72 (3.63, 16.4) | 1.00E-07 | |||
MVMR Egger | 14.02 (5.42, 36.28) | 5.00E-08 | |||||
Ridge Regression | 7.70 (2.94, 16.23) | ||||||
HPV-positive HNSCC vs controls | CSI | 30.4 | 174.8 | 0.63 | IVW | 2.73 (1.39, 5.36) | 0.003 |
MVMR Egger | 2.05 (1, 4.12) | 0.048 | |||||
Ridge Regression | 3.90 (1.62, 9.67) | ||||||
Drinks per Week | 6.13 | IVW | 2.66 (1.06, 6.68) | 0.038 | |||
MVMR Egger | 6.51 (2.01, 21.12) | 0.002 | |||||
Ridge Regression | 2.49 (0.89, 5.63) |
