Fig. 5: Analysis of cancer associated fibroblasts.
From: METI: deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics
a Pathology annotation of fibroblast-enriched spots in STAD G2. b Fibroblasts segmentation result (left), accompanied by 3D fibroblast density plots (right). c Total UMI counts for individual spots. d Pixel-level meta gene expression plot for CAF (left), with annotations highlighting regions of elevated CAF gene expression on the corresponding H&E image (right). e Pixel-level meta gene expression plot specifically for myCAF (left), accompanied by annotations indicating regions of elevated myCAF gene expression on the H&E image (right). f Pixel-level meta gene expression plot for iCAF (left), with annotations denoting regions of elevated iCAF gene expression on the H&E image (right). g Pixel-level meta gene expression plot for apCAF (left), with annotations indicating regions of elevated apCAF gene expression on the H&E image (right). h Overlay showcasing regions of high gene expression for myCAF, iCAF, apCAF, and general CAF.
