Fig. 2: Distribution of hotspot mutations by gene and TIER classification.
From: Somatic mutations in 3929 HPV positive cervical cells associated with infection outcome and HPV type
a Distribution of mutated sites classified in each TIER. b Proportion of mutations in each gene by the total number of mutations in each TIER, by status. c Proportion of mutations in each gene by the total number of mutations in each TIER, by HPV type. Mutations from multiple HPV16/18/45 type co-infections were excluded. Footnote: CIN3 Cervical intraepithelial neoplasia grade 3, AIS adenocarcinoma in situ. P-values were estimated with two-sided Fisher’s Exact tests for count data with simulated p-values (based on 2000 replicates). Source data are provided as a Source Data file.
