Fig. 4: Persistent evolutionary characteristics of MPXV in the C.1.1 Lineage. | Nature Communications

Fig. 4: Persistent evolutionary characteristics of MPXV in the C.1.1 Lineage.

From: Evolutionary trajectory and characteristics of Mpox virus in 2023 based on a large-scale genomic surveillance in Shenzhen, China

Fig. 4

Total ratio (A) and average number (B) of 12 types of substitutions across all lineages among MPXV clade IIb. Total ratio (C) and average number (D) of 5 types of mutaions across all lineages among MPXV clade IIb. Significant differences found in APOBEC3-like TC > TT mutation (E) and APOBEC3-like GA > AA mutation (F) across all clade IIb MPXV genomes. Significant differences found in missense mutations (G), synonymous mutations (H) and non-coding region mutations (I) across all MPXV clade IIb genomes. Boxplots showed the first quartile (minima), the third quartile (maxima), and the median (the solid line in the box plots) value of mutation number in each lineage. Significance was examined using one-way ANOVA among all groups and two-sided Student’s t-test between two groups. Significance level were represented by black asterisks, with * indicating p < 0.05, ** indicating p < 0.01, *** indicating p < 0.001 and **** indicating p < 0.0001.

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