Fig. 5: Replication analyses of HMO-associated loci in the INSPIRE Study. | Nature Communications

Fig. 5: Replication analyses of HMO-associated loci in the INSPIRE Study.

From: Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children

Fig. 5: Replication analyses of HMO-associated loci in the INSPIRE Study.

a–c Overlayed regional plots show replication of HMO-associated loci in the INSPIRE sub-cohort (N = 395): significant replications after Bonferroni correction for multiple testing surpass the red horizontal line. a SNP rs4234598 in locus 3q27.3 was associated with both 6’SL and LSTc. b Four SNPs in 7q31.32 were associated with LNT and one SNP (rs16869462) in 7q21.32 is associated with LNH. c A total of 41 SNPs in 19p13.2 and 19q13.33 loci were associated with all HMOs except 6’SL and LNnT in the INSPIRE sub-cohort. d Overlayed Manhattan plot of the meta-analyses of 19 HMOs combining the CHILD and INSPIRE sub-cohorts (N = 1375). Loci in red exceeded the genome-wide significance threshold (meta-P < 5e–08) and loci in green were suggestively associated (meta-P < 1e–05). Out of the 6 associated genomics regions, two were novel (7q21.32 and 13q33.3), not previously identified in either the CHILD or INSPIRE sub-cohorts alone.

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