Fig. 4: Further transformation of N-oxides.
From: Asymmetric N-oxidation catalyzed by bisguanidinium dinuclear oxodiperoxomolybdosulfate
a Condensation conditions: N-oxide (0.05 mmol, 1.0 equiv.), drug (1.2 equiv.), DMAP (5 mol%), EDCI (1.2 equiv.) in DCM at RT for 4–6 h. For products 6 and 9, racemic drugs were used. The isolated yields were given, The er values were determined by HPLC analysis on a chiral stationary phase. b Reaction conditions: amine (0.05 mmol, 1.0 equiv.), BG5 (8 mol%), Ag2MoO4 (10 mol%), KHSO4(0.3 equiv.), and 25% aqueous H2O2 (1.2 equiv.) in 1.0 mL iPr2O at 0 °C for 48 h, The isolated yield was given, The er value was determined by HPLC analysis on a chiral stationary phase.
