Fig. 2: Cryo-EM reconstructions of human RyR2 variants show that the primed state is reversed by treatment with the Rycal ARM210. | Nature Communications

Fig. 2: Cryo-EM reconstructions of human RyR2 variants show that the primed state is reversed by treatment with the Rycal ARM210.

From: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders

Fig. 2

RMSD-normalized projections of the primed PKA-phosphorylated CPVT and HF variants in the absence and presence of ARM210. Values close to 0 or 1 indicate the conformation of the cytoplasmic shell is more similar to the closed WT RyR2, or the open WT RyR2, respectively. Negative values indicate the conformation of the cytoplasmic shell is more upward-inward than the closed state.

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