Fig. 1: Overall structure of the mTAAR7f-Gs complex.
From: Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f
a Cryo-EM density of the entire complex. b Cartoon of the mTAAR7f-Gs complex (ribbon representation) with bound DMCHA (pale blue) and CHS (pale brown) shown as spheres. The inset shows density for DMCHA (pale blue) and surrounding residues (purple) in mesh. The view is from the extracellular surface and is 90° orthogonal to the receptor cartoon viewed in the membrane plane. c The three most populated ligand binding poses derived from MD simulations conducted either in the absence or presence of the G protein (ligand orientation from the cryo-EM structure is shown in grey) are shown in stick representation. d Differences in ligand RMSD from five distinct MD simulations either with or without G protein are depicted. The error bars represent the SD and a two-sided t-test showed no statistical difference (ns; p = 0.94) between the mean ligand RMSDs.
