Fig. 2: Trajectory of pore loop-1 (PL1) motion during substrate translocation.
From: Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway
A Overlay of all nine models of PL1 (residues 287-289, D1; 560-562, D2) wrapped around substrate (purple). Subunit E residues disengaged from substrate are indicated as E*. B Position of PL1 models from subunits E and F relative to substrate. C Positioning of subunit E PL1 models along the path of subunit F reveals the continuous trajectory of a substrate-disengaged subunit from the bottom to the top of each helical stack. Substrate axis represented as purple rod. The end positions of the transitioning subunit inferred from extrapolation of the helical assembly are colored blue, with intermediate states inferred from class 1–9 conformations of subunits E* and F shown in gray.
