Table 2 Association of virologic factors with post-acute sequelae of SARS-CoV-2 infection (PASC) (N = 104)

From: Early biological markers of post-acute sequelae of SARS-CoV-2 infection

 

Non-PASC N = 72, median (IQR)

PASC

N = 32, median (IQR)

Incidence Ratiosc (95% CI)

p-value

Maximum RNA N viral loada

6.7 (4.8 to 8.3)

8.3 (7.2 to 9.5)

1.21 (1.03 to 1.43)

p = 0.02

Maximum RNA E viral load

6.3 (4.7 to 7.9)

7.6 (6.7 to 8.6)

1.18 (1.01 to 1.39)

p = 0.03

Maximum infectious viral loada,b

5.3 (3.0 to 6.1)

5.2 (4.2 to 5.9)

1.08 (0.90 to 1.32)

p = 0.43

Rate of RNA N viral decay

−0.3 (−0.5 to −0.1)

−0.4 (−0.5 to −0.2)

0.66 (0.26 to 1.70)

p = 0.39

Rate of RNA E viral decay

−0.4 (−0.6 to −0.2)

−0.5 (−0.7 to −0.3)

0.73 (0.46 to 1.16)

p = 0.19

  1. aViral load measurements were log-transformed copies/mL.
  2. bAmong 104 participants with a viral measurement, there were 53 (25 PASC, 28 non-PASC) who had maximum infectious viral load assessed.
  3. cIncidence ratios calculated with delta-method standard errors using generalized estimating equations controlling for sex, age, vaccination status, and SARS-CoV-2 variant.
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