Fig. 5: The SARS-CoV-2-nsp5T169Insp12V792I virus efficiently transmitted to contact golden Syrian hamsters. | Nature Communications

Fig. 5: The SARS-CoV-2-nsp5T169Insp12V792I virus efficiently transmitted to contact golden Syrian hamsters.

From: Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections

Fig. 5: The SARS-CoV-2-nsp5T169Insp12V792I virus efficiently transmitted to contact golden Syrian hamsters.

a Experimental design. b Changes in body weight of hamsters following intranasal inoculation of SARS-CoV-2-nsp5T169Insp12V792I and WT viruses and in contact animals throughout the 14-day experimental period. c SARS-CoV-2 RNA load in oropharyngeal swabs quantified by rRT-PCR. (b-c) Data represents mean ± SEM of four animals/group/timepoint. d, e Infectious SARS-CoV-2 loads in oropharyngeal swabs determined using endpoint dilutions and expressed as TCID50.mL−1. f SARS-CoV-2 RNA load in nasal turbinate, trachea and lungs quantified by rRT-PCR. g Neutralizing antibody responses to SARS-CoV-2 assessed by virus neutralization assay (100% neutralization) in serum. d–g Data represents median of four animals/group/timepoint. a Created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license.

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