Fig. 6: Carriage of virulence factors (VFs) in viral genomes and its relationship with ARG-carriage.

Overall incidence of VFs in genomes of (A) NCLDVs and (E) phages. Possibility of ARG-carriage in the VF- and VF+ genomes in (B) NCLDVs and (F) phages. Two-sided Chi-squared test is performed to test dependency between VF-carriage and ARG-carriage in the viral genomes. Family composition of the genomes carrying both ARGs and VFs in (C) NCLDVs and (G) phages. Genomic potential of ARG-carriage in VF- and VF+ genomes in (D) NCLDVs and (H) phages. Two-sided Wilcoxon rank-sum test is performed to evaluate the statistical significance of the differences in genomic potential of ARG carriage between VF+ and VF- genomes. Data are presented as mean values ± SEM. Each data point is one genome. n = 453 (VF-) and 963 (VF + ) for NCLDVs. n = 38,310 (VF-) and 1967 (VF + ) for phages. The y-axis was truncated to zoom in on values below 0.05% in (H). VF + : genomes with at least one VF. VF-: genomes without any VF. Source data are provided as a Source Data file on Github¹⁰⁷.