Fig. 6: Intrinsic sex differences in functional connectivity (FC) profiles and network topology.
A Number of connections (per seed region) showing statistically significant false discovery rate (FDR)-corrected sex differences in their odds of belonging to the given seed’s top 10% connections; B Functional network breakdown of connections showing statistically significant FDR-corrected sex effects in their odds of belonging to the given seed’s top 10% connections. The outer ring displays absolute proportions of statistically significant cortical areas by functional Yeo network, the inner ring displays absolute nested proportions by directionality of effects, where blue represents higher male odds and red represents higher female odds; C Connections between seed and target regions showing statistically significant FDR-corrected sex differences in FC profiles (odds ratio (OR) > 1 meaning that males have higher odds than females of having a target region belong to a seed region’s top 10% connections; OR < 1 meaning that females have higher odds than males of having a target region belong to a seed region’s top 10% connections; connections are color coded by Yeo network and weighed by number of connections between the network pairs; D β values of linear mixed effect model (LMM) results for the sex contrast in between-network (BN) dispersion for each pairwise Yeo network comparison, where blue represents higher male BN dispersion and red represents higher female BN dispersion (no statistically significant sex effects after spin permutation and multiple comparisons Bonferroni correction; two-sided pspin < 0.001); E β values of LMM results for the sex contrast in within-network (WN) dispersion for each Yeo network (displayed as white dots), plotted on null distributions of β values derived from 1000 spin permutations, where positive β values represent higher male WN dispersion and negative β-values represents higher female WN dispersion. * indicates multiple comparisons Bonferroni-corrected (pspin < 0.004) two-sided statistical significance of the sex contrast for dispersion in the DMN, β = 0.241, pspin < 0.001. β standardized beta coefficient. Source data are provided as a Source Data file.
