Fig. 1: Miami plot of the neonatal and maternal GWAS of neonatal jaundice and associations at UGT1A* gene region.
From: Genome-wide analyses of neonatal jaundice reveal a marked departure from adult bilirubin metabolism
A Miami plot of the GWAS on neonatal jaundice using the neonatal (top, n = 27,384 neonates, cases = 1826) and maternal (bottom, n = 29,182, n cases = 2401) genomes. Genome-wide significant loci are named by their nearest protein coding gene or gene family. The x-axis shows the chromosome position and the y-axis the two-sided p value of the GWAS. The dashed line represents the genome-wide significance threshold (p value = 5 × 10−8). The bar plot shows the risk of neonatal jaundice by rs6755571 genotype, a missense variant affecting UGT1A4. Error bars in the bar plot represent the 95% CI of the estimate. B A regional plot of the genetic associations with UGT1A1 expression in the colon and liver and with neonatal jaundice at the UGT1A* genes region. Y-axis shows the two-sided p value of the eQTL associations between the variants and UGT1A1 expression in colon or liver (from the eQTL Catalog) and neonatal jaundice (from this study, neonatal genome, n = 27,384, cases = 1826). Highlighted are the missense variant (rs6755571, diamond) and variants in LD with it. LD was estimated in 23,196 non-related neonates from MoBa.
