Fig. 3: Neonatal jaundice effects of adult bilirubin level variants and polygenic score.
From: Genome-wide analyses of neonatal jaundice reveal a marked departure from adult bilirubin metabolism
A Genetic effects of the variants at the UGT1A* genes region. Y-axis shows the two-sided p value of the associations between the variants and adult bilirubin levels (a previous publication) or neonatal jaundice (from this study, neonatal genome, n = 27,384, cases = 1826). Highlighted are the top adult variant (rs887829, diamond) and variants in LD with it. LD was estimated in 23,196 non-related mothers from MoBa. B Jaundice prevalence by polygenic score of adult bilirubin levels, including or excluding the UGT1A* genes region, observed in 23,196 neonates (cases = 1569). Weights for the polygenic score of adult bilirubin levels were obtained from the PGS Catalog (ID: PGS002160). Dots represent the neonatal jaundice prevalence, and the error bars the 95% CI.
