Fig. 4: Heat map of the simulated, apparent killing rate for cabamiquine and pyronaridine at 6, 12, 48, and 72 h for the typical IEV P. falciparum wild-type field isolates using the population parameters of the mixed effects model illustrating the time-dependent killing for cabamiquine and stable killing for pyronaridine. | Nature Communications

Fig. 4: Heat map of the simulated, apparent killing rate for cabamiquine and pyronaridine at 6, 12, 48, and 72 h for the typical IEV P. falciparum wild-type field isolates using the population parameters of the mixed effects model illustrating the time-dependent killing for cabamiquine and stable killing for pyronaridine.

From: Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data

Fig. 4: Heat map of the simulated, apparent killing rate for cabamiquine and pyronaridine at 6, 12, 48, and 72 h for the typical IEV P. falciparum wild-type field isolates using the population parameters of the mixed effects model illustrating the time-dependent killing for cabamiquine and stable killing for pyronaridine.

The color gradient depicts the killing rate (green faster; pink slower), while the isoboles visualize lines where the killing rate is identical. The red isobole refers the EC50.

Back to article page