Table 2 Comparison of single drug EC50 values obtained in combination for IEV wild-type and cabamiquine-resistant P. falciparum field isolates

From: Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data

 

IEV WT EC50 (nM)

IEV WT EC50 (nM) adaptive resistance

Resistant isolate 1 EC50 (nM)

Resistant isolate 2 EC50 (nM)

Cabamiquinea

0.779

5.9

961

5 × 1015

Pyronaridine

28.3

–

12.9

7.62

Pyronaridine (in combinationb)

28.3

–

1.29 (due to synergy)§

7.62

  1. aCabamiquine values for monotherapy and combination, §P value < 1e-6.
  2. bIf cabamiquine exceeds a concentration of 61.6 nM.
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