Fig. 6: Model of vitamin A or radical-trapping antioxidants suppressing ferroptosis to promote neuronal development. | Nature Communications

Fig. 6: Model of vitamin A or radical-trapping antioxidants suppressing ferroptosis to promote neuronal development.

From: Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development

Fig. 6

This graphical summary shows that lipid peroxidation and ferroptosis must be suppressed to generate mature neurons. This is achieved either through the action of radical-trapping antioxidants (RTAs) or by transcriptional up-regulation of ferroptosis gatekeepers GPX4, FSP1, GCH1, and ACSL3 by all-trans retinoic acid (vitamin A). Vitamin A has a dual function in suppressing ferroptosis as both retinal and retinol have RTA activity.

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