Table 1 Comparison of the effects of the 10-week combination exposure to HFD and L-NAME on Pdgfra-PKN1/2 WT and KO and on cmc-PKN1/2 WT and KO male mice

From: Protein kinase N promotes cardiac fibrosis in heart failure by fibroblast-to-myofibroblast conversion

 

Control

HFpEF

 
 

Pdgfra- PKNwt/wt (n = 10)

Pdgfra- PKNflox/flox (n = 10)

Pdgfra- PKNwt/wt (n = 10)

Pdgfra- PKNflox/flox (n = 10)

 

Body weight (g)

21.15 ± 1.27

20.08 ± 0.87

38.31 ± 2.45

39.37 ± 3.35

ns

Systolic blood pressure (mmHg)

105.1 ± 10.3

106.1 ± 8.2

134.4 ± 14.9

135.3 ± 9.3

ns

Heart weight/Tibia length (mg/mm)

5.06 ± 0.10

4.90 ± 0.07

5.90 ± 0.16

5.85 ± 0.12

ns

 

cmc-PKNwt/wt (n = 6)

cmc-PKNflox/flox (n = 6)

cmc-PKNwt/wt (n = 6)

cmc-PKNflox/flox (n = 6)

 

Body weight (g)

26.13 ± 1.17

25.72 ± 1.22

39.17 ± 2.32

39.50 ± 2.17

ns

Systolic blood pressure (mmHg)

107.3 ± 6.9

106.8 ± 3.1

138.7 ± 4.6

140.5 ± 8.1

ns

Heart weight/Tibia length (mg/mm)

4.88 ± 0.32

4.80 ± 0.28

5.96 ± 0.49

6.28 ± 0.55

ns

  1. Body weight, systolic blood pressure, and ratio of heart weight to tibial length after 10-week combination exposure to HFD and L-NAME in Pdgfra-PKN1/2 WT and KO, and in cmc- PKN1/2 WT and KO male mice. Data are presented as the mean ± SEM and analyzed using two-way ANOVA followed by Tukey’s post hoc test. ns, not significant. The data represent three independent experiments with similar results. Source data are provided as a Source Data file.
Back to article page