Fig. 2: AD/LB groups and global cognitive functioning.
From: Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease
Figure illustrates AD/LB group differences for (A, B) cross-sectional cognition based on the two-sided generalized linear model (n = 795) and (C, D) longitudinal cognitive performance based on the two-sided linear mixed models. All models were corrected for baseline age, sex, cognitive state, and level of education. Boxplots show the median, lower, and upper quartiles with whiskers representing minimum and maximum values. The spaghetti plots illustrate raw data regarding cognitive performance over time, while lines represent model fits (shaded area reflect 95% confidence interval). Models including an additional quadratic term for time better described the data. Lines within figure represent significant differences in AD/LB group*time2. Only p-values adjusted for multiple comparison are shown. *padjusted < 0.05, **padjusted < 0.01, ***padjusted < 0.001.
