Fig. 6: Number of genes shared between IDPs and risk factors. | Nature Communications

Fig. 6: Number of genes shared between IDPs and risk factors.

From: Phenotypic and genetic characteristics of retinal vascular parameters and their association with diseases

Fig. 6

a Gene-scoring plain intersection. Each cell shows the number of intersected genes in phenotype pairs. b, c Cross-phenotype coherence analysis showing the number of coherent (b) and anti-coherent (c) genes between phenotype pairs. Summary statistics for risk factors were obtained from http://www.nealelab.is/uk-biobank (see for risk factor sample sizes). Gene-level p-values were derived from two-sided Chi-square test statistics using PascalX57 and corrected for multiple testing with the Bonferroni method (significance threshold set to 0.05/number of tested genes). Risk factor genetic sample sizes: DBP and SBP: 340 k; High BP: 360 k; PR: 340 k; Pulse wave ASI: 118 k; HDL cholesterol: 315 k; LDL direct: 344 k; Triglycerides: 344 k; HbA1c: 344 k; Alcohol intake frequency: 361 k; Smoking status: 360 k; BMI: 360 k. And, IDPs genetic sample sizes: A temporal angle: 55 k; V temporal angle: 58 k; A/V and ratio tortuosity: 68 k; A, V and ratio central retinal eq: 65 k; A/V std diameter and bifurcations: 68 k; A/V and ratio vascular density: 68 k; A/V and ratio median diameter: 68 k. Retinal IDP sample sizes are listed in the ‘N GWAS’ column in Supplementary Table 2.

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