Fig. 7: Illustration of critical findings of this study.
From: ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency
ZIC2 and ZIC3 have largely overlapping roles and act together as crucial regulators of human primed pluripotency, facilitating recruitment of the SWI/SNF complex over primed hESC-specific enhancers. Their simultaneous ablation in primed hESCs results in selective closing of lineage-specific enhancers, a failure to self-renew or maintain primed pluripotency, and a gene expression pattern indicative of disrupted PRC2 activity coincident with aberrant expression of mesendoderm genes. Their ectopic expression in naïve hESCs facilitates progression towards primed pluripotency in a SWI/SNF-dependent manner.
