Fig. 4: The mFabT strain displays adhesion and growth defects in the presence of human cells or in conditioned cell supernatant.

a–d Comparison of WT and mFabT strain adhesion and growth capacities in the presence of human cells, or conditioned supernatants. Endometrial cells, undifferentiated keratinocytes, and differentiated keratinocytes, and their respective conditioned supernatants were used as specified. a Adhesion; b, c, growth (cfu.mL⁻¹). d, left, Bacterial growth kinetics in endometrial conditioned supernatants; right, Live/Dead bacteria assessment after 8 h growth in conditioned supernatants. Growth experiments were started with 10³ bacteria per ml. Determinations were based on N = 9, 7, 7 for a (left to right), N = 11, 9, 6 for (b) (left to right), N = 8, 7, 9 for (c) (left to right), and N = 3 for (d). In each case N corresponds to the number of independent biological replicates performed per condition. Analyses were done as follows: a, b Wilcoxon test for endometrial samples, two-sided T-test for keratinocytes; c Wilcoxon test for endometrial cells and undifferentiated keratinocytes, two-sided T-test for differentiated keratinocytes; d 2-way ANOVA, Bonferroni post-test. Significant p-values are shown. a–c Outliers were searched using ROUT method (GraphPad), with Q = 1%. All graphs are presented as mean values +/- SEM. WT, white bars; mFabT, green bars. Source data for (a), (b), (c), and (d) are provided as a Source Data file.