Fig. 7: Applications to total synthesis of natural products and their structural analogs.

a Asymmetric synthesis of (+)-gemmacin and (+)-gemmacin B. b Preparation of close structural analogs of (+)-gemmacin and (+)-gemmacin B. dtbbpy, 4,4’-di-tert-butyl-2,2’-dipyridyl; DMF, N,N-dimethylformamide; THF, tetrahydrofuran; TsOH, p-toluenesulfonic acid; TFA, trifluoroacetic acid; 1,2-DCE, 1,2-dichloroethane.