Fig. 7: A proposed model for the regulation of α-tubulin lactylation.
From: Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation
The glycolysis is crucial for energy generation in cells and results in the production of lactate. HDAC6 functions as a lactyltransferase to lactylate the α-tubulin K40 residue by using lactate, facilitating microtubule dynamics. HDAC3 catalyzes lactate to enhance lactylation of microtubule-associated proteins that may also affect cytoskeleton functions.
