Fig. 1: Integrative model of the PInC unveils the overall structural organization of the assembly. | Nature Communications

Fig. 1: Integrative model of the PInC unveils the overall structural organization of the assembly.

From: Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair

Fig. 1

a View of the PInC assembly colored by subunits. XPG, XPF/ERCC1, p62, and DNA are shown in cartoon representation. TFIIH, XPA, and RPA are shown in surface representation. The lesion containing DNA strand is shown in cyan; the undamaged strand is shown in blue. b Domain organization of the PInC constituent proteins XPG, XPF, ERCC1, XPA, RPA, XPB, XPD, and p62 mapped onto their respective sequences. Abbreviations denote H.W.—hydrophobic wedge; GH—gateway helix; CH—coiled-coil helix; H2TH—helix-2-turn-helix; H.D.—helicase domain; HhH—helix-hairpin-helix; DRD—damage recognition domain; NTE—N-terminal extension. c Schematic showing the DNA substrate of PInC, the length of the NER bubble, and the positions of the lesion site (red star) and the two incision sites (red scissor symbols).

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