Fig. 5: RPA binds and protects the undamaged strand, engaging ssDNA with its 70A, 70B and 70C domains. | Nature Communications

Fig. 5: RPA binds and protects the undamaged strand, engaging ssDNA with its 70A, 70B and 70C domains.

From: Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair

Fig. 5

a Schematic representation of RPA’s DNA-binding core with the ssDNA of the undamaged strand. The ssDNA is engaged by three OB-fold domains (70A-70B-70C). b View of RPA within the PInC assembly. RPA is shown in cartoon representation and colored in purple. c View of RPA70AB situated near the 3′ junction and interacting with XPG and XPD. RPA70AB is colored by domains. d View of the RPA trimer core engaging ssDNA at the 5′ junction. The XPA zinc finger is wedged between RPA70C and 32D. e A view of XPA’s N-terminal XPA lodged between the RPA32C and RPA14 domains.

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