Fig. 8: NER protein machinery undergoes a dramatic structural reorganization from lesion recognition to lesion scanning and strand incision. | Nature Communications

Fig. 8: NER protein machinery undergoes a dramatic structural reorganization from lesion recognition to lesion scanning and strand incision.

From: Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair

Fig. 8: NER protein machinery undergoes a dramatic structural reorganization from lesion recognition to lesion scanning and strand incision.The alternative text for this image may have been generated using AI.

The schematic represent key steps in the NER pathway—XPC lesion recognition, NER bubble extension, XPD-mediated lesion scanning, PInC assembly and dual incision of the damaged DNA segment, gap-filling synthesis, and DNA restoration. Core NER factors are shown in cartoon representation and color-coded. The position of the lesion is indicated by a red star. Red dashed arrows show the direction of ssDNA movement during the different stages of NER. White dotted arrow denotes the opening/closing dynamics of XPB during bubble expansion. Black dotted arrow denotes the opening/closing dynamics of XPD during lesion scanning. A red cross denotes the blocking of a lesion inside XPD and damage verification. Red arrows indicate the incision points on DNA by XPF/ERCC1 and XPG, respectively.

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