Fig. 8: NER protein machinery undergoes a dramatic structural reorganization from lesion recognition to lesion scanning and strand incision. | Nature Communications

Fig. 8: NER protein machinery undergoes a dramatic structural reorganization from lesion recognition to lesion scanning and strand incision.

From: Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair

Fig. 8

The schematic represent key steps in the NER pathway—XPC lesion recognition, NER bubble extension, XPD-mediated lesion scanning, PInC assembly and dual incision of the damaged DNA segment, gap-filling synthesis, and DNA restoration. Core NER factors are shown in cartoon representation and color-coded. The position of the lesion is indicated by a red star. Red dashed arrows show the direction of ssDNA movement during the different stages of NER. White dotted arrow denotes the opening/closing dynamics of XPB during bubble expansion. Black dotted arrow denotes the opening/closing dynamics of XPD during lesion scanning. A red cross denotes the blocking of a lesion inside XPD and damage verification. Red arrows indicate the incision points on DNA by XPF/ERCC1 and XPG, respectively.

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