Fig. 4: Z-Stereoselective Cross-Metathesis (CM) reactions.

A Z-selective CM made with Ru3 under reduced pressure without solvent (neat conditions). B Comparison of Ru2 and Ru3 in Z-selective CM under classical conditions (in THF solution). C Examples of complex polyfunctional API-derived molecules obtained in Z-selective CM. Yields of isolated pure products. API active pharmaceutical ingredients. The tablet icon is from Font Awesome’, Copyright (c) 2024 Fonticons, Inc. (https://fontawesome.com).