Fig. 1: UHRF1 is overexpressed in cancer and promotes tumor growth in syngenic mouse models.
From: Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response
a UHRF1 expression in cancers versus normal tissues. TPM, transcripts per million. BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; CESC, cervical squamous cell carcinoma; CHOL, cholangiocarcinoma; COAD, colon adenocarcinoma; ESCA, esophageal carcinoma; GBM, glioblastoma multiforme; HNSC, head and neck squamous cell carcinoma; KICH, kidney chromophobe; KIRC, kidney renal clear cell carcinoma; KIRP, kidney renal papillary cell carcinoma; LIHC, liver hepatocellular carcinoma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; PRAD, prostate adenocarcinoma; READ, rectum adenocarcinoma; STAD, stomach adenocarcinoma; THCA, thyroid carcinoma; UCEC, uterine corpus endometrial carcinoma; SKCM, skin cutaneous melanoma. b UHRF1 expression in GSE32867 dataset (n = 58). c Survival analysis of lung cancer patients stratified by UHRF1 mRNA expression (n = 376 low, 1035 high). d UHRF1 Protein expression in Gillett et al. cohort (n = 102). e Survival analysis based on UHRF1 protein expression in Xu et al. cohort (n = 56 low, 9 high). f, g Tumor photos for LG1233 with 1 × 105 (f) or 1 × 106 (g) cells injected into female C57BL/6 mice. h, i Tumor growth (h) and survival(i) curves for LG1233 cells injected into female C57BL/6 mice. n = 7 per group. j, l Tumor photo (j) and growth curves (l) for LLC-OVA cells injected into female C57BL/6 mice. n = 7 (shNT), 8 (shUhrf1). k, m Tumor photo (k) and growth curves (m) for LLC-OVA cells injected into male nude mice. n = 5 per group. Data are mean ± SEM (h, l, m). For box plots, the box limits show the 25th to 75th percentile, the centre line shows the median value and the whiskers show the minimum to maximum values. n indicates the number of biological replicates. P values were determined using two-sided Wilcoxon signed-rank test (a, b, d), log-rank test (c, e, i), two-way ANOVA test (h, l, m). Source data are provided as a Source Data file. Data in (h, i, l, m) were repeated independently at least twice with similar results.
