Fig. 2: Architecture of the NbE-µOR complex.
From: Structural basis of μ-opioid receptor targeting by a nanobody antagonist
a Cryo-EM map (left) and ribbon representation (right) of the NbE-µOR-Fab module complex, with the murine µOR colored in blue, NbE in red, the heavy and light chains of the Fab fragment in sky blue and light pink, respectively, and the anti-Fab nanobody (FabNb) in yellow (b) The NbE-µOR complex as ribbon representation, with a focus on the NbE-µOR interface. NbE deeply inserts its CDR3 β-hairpin loop into the orthosteric binding pocket. For reasons of clarity the Fab module is omitted. CDR1, 2, and 3 are highlighted in yellow, dark blue and dark red, respectively. Otherwise color-coded as in (a).
