Fig. 7: Model describing the role of mitochondria in maintaining NADPH homeostasis. | Nature Communications

Fig. 7: Model describing the role of mitochondria in maintaining NADPH homeostasis.

From: Compensatory activity of the PC-ME1 metabolic axis underlies differential sensitivity to mitochondrial complex I inhibition

Fig. 7

Proposed model showing how mitochondrial-derived malate in intact cells, can sustain NADPH levels in the absence of optimal PPP activity. Conversely, cells with severe impairments in the ETC redirect pyruvate and/or glutamine through non-canonical TCA cycle as sources to generate malate. Under these conditions, ETC-deficient cells heavily rely on ME1 expression to maintain NADPH levels and ensure cellular fitness. This figure was created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license.

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