Fig. 8: Cell lineage hierarchy and cancer-prone cell state of the distal tubal epithelium.
From: Pre-ciliated tubal epithelial cells are prone to initiation of high-grade serous ovarian carcinoma
The hierarchy begins with Slc1a3+ stem/progenitor cells giving rise to secretory and ciliated cell lineages. Slc1a3+ stem/progenitor cells undergo apoptosis after inactivation of Trp53 alone or together with Rb1, while inactivation of Trp53 and Rb1 in Krt5+ pre-ciliated transitional cells lead to high-grade serous carcinoma. Colors of epithelial cells resemble the colors used to label cells within UMAP embeddings (Fig. 2a).
