Fig. 5: Extending the pathway to biosynthesize palmatine in module IV and berberine in module V. | Nature Communications

Fig. 5: Extending the pathway to biosynthesize palmatine in module IV and berberine in module V.

From: De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast

Fig. 5: Extending the pathway to biosynthesize palmatine in module IV and berberine in module V.

a Schematic presentation of module IV and module V. b (S)-THP and (S)-canadine titers in strains XJ0839 and XJ0834, respectively. c 36h-heating of fermentation broth led to increased palmatine and berberine titers. Significance was calculated using two-tailed t-test. Data are presented as mean ± standard deviations (n = 3 biologically independent samples). Source data are provided as a Source Data file.

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