Fig. 2: HEV replication detected in the liver but not in the kidney. | Nature Communications

Fig. 2: HEV replication detected in the liver but not in the kidney.

From: HEV ORF2 protein-antibody complex deposits are associated with glomerulonephritis in hepatitis E with reduced immune status

Fig. 2: HEV replication detected in the liver but not in the kidney.The alternative text for this image may have been generated using AI.

a Viral load using RT-PCR and corresponding semi-quantitative IHC results using 1E6 antibody on FFPE sections. b RNA in situ hybridization using Dap-B negative control (upper panel), PPIB positive control (middle panel) and HEV-specific (lower panel) probes, on non-HEV-replicating Hep293TT cells and HEV-replicating Hep293TT cells40 as well as autopsy liver and kidney transplant tissue (Patient 1). Scale bars: 2 mm; liver: 100 µm; kidney: 100 µm (n = 3 experiments, two sections stained per condition and per experiment). Source data are provided as a Source Data file.

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