Fig. 3: Distributions of orientations of the replicated strands and the H3/H4 tetramer in the simulations of the replicated-DNA-engaged replisome. Source data are provided as a Source Data file.
From: Molecular mechanism of parental H3/H4 recycling at a replication fork
A Definition of X- and Z-axes. B, C Schematic illustrations of the replicated-DNA-engaged replisome, which explains the definition of the elevation (φ) and azimuthal (θ) angles to describe the lagging (B) and leading (C) strand orientation. The color scheme is the same as in Fig. 1B. D, F 1D and 2D probability distributions of the lagging (D) and leading (F) strand orientation calculated from the simulation trajectories until recycling. E, G Iso-surfaces of the spatial probability density of the lagging (E) and leading (G) strand orientation. The iso-value was set to 0.0001 [Å−3]. H Schematic illustrations of the replicated-DNA-engaged replisome explaining the definition of the elevation (φ) and azimuthal (θ) angles to describe the H3/H4 tetramer orientation. I, K 2D distributions of the H3/H4 tetramer orientation calculated from trajectories of the simulations in the absence (I) and presence (K) of charges in the Cdc45 acidic loop. J, L Iso-surfaces of spatial probability distributions of the H3/H4 tetramer orientation in the simulation in the absence (J) and presence (L) of charges in the Cdc45 acidic loop. The iso-value was set to 0.0001 [Å−3]. D, F, I, K The black auxiliary lines, which encircle the populated area in (K), mark the azimuthal angles of 10° and 40° and the elevation angles of 10° and 40°.
