Fig. 1: Manhattan plot showing results for the GWAS meta-analysis of cataracts; p values derived from logistic regression models are two-sided.

Each dot represents a single nucleotide polymorphism (SNP) and the red line represents the threshold for multiple testing correction (p < 5 × 10−8) and the blue line (p < 5 × 10−6). Novel loci are represented in the plot as red dots and are highlighted in purple, whereas previously known loci are presented in black.