Fig. 3: GAD-specific clonotypes are located in multiple gene expression clusters and found in peripheral immune repertoires.
From: Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes
a Circus plot with lines joining cells with identical TCRB and TCRA nucleotide sequences (left) or identical TCRB CDR3 (and unknown or different TCRA) (right). b Circus plots with lines joining cells with similar TCRB CDR3 amino acid sequences (belonging to the same convergence group as per GLIPH algorithm, see Supplementary Table 3), and found in different donors. c Cells whose TCRB CDR3 nucleotide sequence is tracked back in peripheral immune repertoire subsets. d Cells whose TCRB CDR3 amino acid sequence is tracked back in peripheral immune repertoire subsets. c, d blue: HD cells. Red: T1D cells.
