Fig. 4: GAD-specific TCRB CDR3 nucleotide sequences can be tracked back into specific peripheral immune cell subsets. | Nature Communications

Fig. 4: GAD-specific TCRB CDR3 nucleotide sequences can be tracked back into specific peripheral immune cell subsets.

From: Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes

Fig. 4

We browsed the GAD-specific TCRB CDR3 nucleotide sequences into 94 peripheral immune cell repertoires: 31 TN (a), 31 CM (b), 16 Treg (c) and 16 Tscm (d). We classified these repertoires into GAD tandem cohort (if both single-cell and deep sequencing took place) and NGS-only cohort (if we only performed deep sequencing). Colour represents the frequency of the given clonotype in peripheral immune cell repertoires.

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