Fig. 6: A therapeutic potential of rumicidins.
From: Rumicidins are a family of mammalian host-defense peptides plugging the 70S ribosome exit tunnel
a Antibacterial activity and cytotoxicity of rumicidins in comparison with known PrAMPs. MICs were determined in the rich Mueller-Hinton broth (MHB) ± 0.9% NaCl. *The geometric mean of MICs (GM) against tested strains (when the value > 32 µM was observed, the MIC of 64 µM was used for calculation). b Survival rates of BALB/c mice (n = 5) infected intraperitoneally (IP) with E. coli ATCC 25922 (106 bacteria in the presence of 2.5% mucin). Ciprofloxacin (the single dose of 10 mg/kg) and saline were used as positive and negative control, respectively. Mice were controlled once daily for their health status during 7 post-infection days. A high CFU burden in mice from the negative control group was verified. The absence of E. coli in spleen after euthanizing of all survived animals was controlled.
