Fig. 4: Infant rCBF increases according to a hierarchical limbic-sensorimotor-association gradient. | Nature Communications

Fig. 4: Infant rCBF increases according to a hierarchical limbic-sensorimotor-association gradient.

From: Spatiotemporal cerebral blood flow dynamics underlies emergence of the limbic-sensorimotor-association cortical gradient in human infancy

Fig. 4

a Cortical voxels were clustered into three groups (limbic, sensorimotor, and frontoparietal clusters) identified by non-negative matrix factorization (NMF) according to the pattern of rCBF increase over time. The respective locations of the three clusters on the cortical surface are displayed in lateral and medial views. Segmented regression analysis indicates a biphasic developmental pattern of averaged rCBF in each cluster (red line) overlaid on 200 randomly sampled voxel developmental curves from each cluster (gray thin lines). The identified break-point ages (black dashed lines) from segmented regression analysis varied across clusters and were provided at the bottom of each plot. b Histograms showed the profile of break-point age from cortical voxels within each cluster. c rCBF increase rate (ml/100 g/min/month) across cortical voxels within each cluster. d Heterogeneous rCBF increase rate across cortex at milestone ages during infancy. Slower and faster rCBF increase rates are shown in cool and warm colors, respectively. Source data are provided as a Source Data file.

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