Fig. 4: Changes in manifold structure post-stroke and its relation to underlying neuroanatomical organization.

A Left, Average t-values (indicating the change in eccentricity from the Pre- to Post-stroke scan) for each functional network (shown at right). This panel shows that, on balance, regions within the DMN and limbic networks exhibited the largest relative change in manifold embedding following the MCAO stroke. Right, Cortical maps showing the topography of different functional networks (top), myelin concentration (middle) and neurotransmitter receptor density (Receptor PC1, bottom). A visual comparison of these maps highlights that the regions exhibiting the largest changes post-stroke (DMN and limbic areas) tend to also be regions with low myelination (white regions) and a higher density of neurotransmitter receptors per neuron (red regions). B Left, Probability density distribution of myelin concentration for significant (blue) and non-significant (orange) brain regions from Fig. 3D. A two-sample Kolmogorov–Smirnov test revealed a significant difference between distributions (p = 0.001). Right, relationships between change in eccentricity (two-sided T-stat) versus cortical myelination (top), and versus receptor density (bottom). Note that regions with low myelination (top) and greater receptor density (bottom) are significantly associated with a larger change in eccentricity. MCAO: Middle Cerebral Artery Occlusion. DMN: Default Mode Network.