Fig. 5: Diversification to access various enantioenriched molecules. | Nature Communications

Fig. 5: Diversification to access various enantioenriched molecules.

From: Axially chiral α-boryl-homoallenyl boronic esters as versatile toolbox for accessing centrally and axially chiral molecules

Fig. 5

a Synthesis of axially chiral allenyl aldehyde and ketone. b Regio- and chemoselective protodeboronation and subsequent one carbon homologation of (S)−3a. c Synthesis of enantioenriched 2,5-dihydrofuran through regio- and chemoselective protodeboronation, oxidation of Bpin, bromo cyclization and palladium-catalyzed cross-coupling. d Gram-scale synthesis of 4a and its further manipulations. e Synthesis of enantioenriched 1,4-aminoalcohol through oxidation of Bpin and reduction.

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