Fig. 7: Deletion of Tbx5 disrupts the cellular localization of diphosphorylated myosin light chain in the dorsal pericardial wall. | Nature Communications

Fig. 7: Deletion of Tbx5 disrupts the cellular localization of diphosphorylated myosin light chain in the dorsal pericardial wall.

From: Single-cell morphometrics reveals T-box gene-dependent patterns of epithelial tension in the Second Heart field

Fig. 7: Deletion of Tbx5 disrupts the cellular localization of diphosphorylated myosin light chain in the dorsal pericardial wall.The alternative text for this image may have been generated using AI.

a–a″ Ventral whole-mount views of E9.5 wildtype DPW stained with phalloidin (white), ppMLC (blue) and Tbx5 (red). b High magnification view of the posterior DPW in wild-type embryos; white arrows indicate the accumulation of ppMLC at the long membranes of the cells. c–c″ Ventral whole mount views of E9.5 Mef2cAHFCre;Tbx5fl/fl mutants stained with phalloidin (white), ppMLC (blue) and TBX5 (red). d High magnification view of the posterior DPW region in Mef2cAHFCre;Tbx5fl/fl embryos, showing no accumulation of ppMLC at the long membranes of the cells. Wild-type E9.5: N = 5 embryos; Mef2cAHFCre;Tbx5fl/fl: N = 4 embryos. Scale bars: 50 µm.

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