Fig. 6: EBV latent proteins have elevated mimicry and viral mimicry targets negatively selected proteins.
From: Molecular mimicry as a mechanism of viral immune evasion and autoimmunity
a Schematic of latent vs. lytic stages of viral replication. b Percent of 12mers with 0, ≤1, ≤2, and ≤3 mismatches in latent and lytic EBV proteins. Each point denotes a single EBV protein connected across the mismatch levels with boxplots denoting the median as the midline, the bounds of the box defining the 25th and 75th percentile, and the whiskers denoting the 1.5 times the interquartile range. For comparison of latent vs. lytic genes in (b), the Wilcoxon summed-rank test was used with Benjamini–Hochberg corrections (*p.adj ≤0.05 and **p.adj ≤0.01). For b latent genes n = 8 and lytic genes n = 84. c Percent difference of mimics expressed in mTEC, CD19+ B cells, CD141+ dendritic cells, CD123+ dendritic cells, or “any” of these cells in the human thymus (all antigen presenting cells), compared to the percentage of all human genes expressed by the cell type (as determined by RNA expression in Gabrielsen et al.26). Adjusted p value calculated using fisher exact test (two-sided) with Benjamini–Hochberg corrections. Source data are provided as a Source Data file.
